Endocrine Abstracts

DHEA and its sulphate derivative DHEA-sulphate (DHEA-s) are major androgen hormones of adrenal origin. The purpose of this study was to investigate DHEA-s levels in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and to determine whether DHEA-s levels are a useful marker in the diagnosis of hypogonadotropic hypogonadism. 91 subjects, 31 male patients diagnosed with IHH (mean age 19.7±2.6 years) and 60 healthy males (mean age 20.7±2.6 years) as a con...

Thyroid disorders and polycystic ovary syndrome (PCOS) are two of the most common endocrine disorders in general population. Autoimmune thyroid diseases are common autoimmune disorders that affect about 5% to 20% of women in childbearing age. In this study, we evaluate the comorbidity rate of euthyroid Hashimoto’s Thyroiditis (HT) in PCOS patients and possible influence of thyroid autoantibodies on clinical and laboratory findings of PCOS. This study includes 285 PCOS pat...

Purpose: The purpose of this study was to evaluate the relation gestational diabetes mellitus (GDM) and the thiol/disulfide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Material/Methods: Thirty one subjects diagnosed with GDM and 30 healthy pregnant women were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method in this study. After native thiol, t...

Familial hypocalciuric hypercalcemia is an inherited disease caused by inactivating heterozygous mutations in the gene encoding calcium-sensitive receptors, that affects calcium metabolism and generally follows a benign course. It must be also considered in the differential diagnosis of hyperparathyroidism. Six patients presenting to our internal diseases clinic between January, 2010, and June, 2015, were evaluated in terms of clinical and biochemical parameters. The youngest ...

Introduction and aims: Polycystic ovary syndrome (PCOS) is a frequent endocrinopathy among with young women. It is known that insulin resistance is encountered in the vast majority of the women with PCOS and hence the risk of type 2 diabetes mellitus and coronary artery disease are increased. These cardiac and metabolic risk increments may also associated with hyperandrogenemia and dyslipidemia. The metabolic changes of lipid profiles in young women with PCOS are not completel...

Introduction: Autoimmune thyroiditis (AIT), also called Hashimoto thyroiditis or chronic lymphocytic thyroiditis is characterized by destruction of the thyroid gland involving apoptosis of thyroid epithelial cells. It usually presents as euthyroidism or subclinically hypothyroidism, rarely as overt hypothyroidism. The cause of Hashimoto’s thyroiditis is thought to be a combination of genetic susceptibility and environmental factors. Bisphenol A (BPA), an endocrine-disrupt...

Introduction: The aim of this study, left ventricular systolic and diastolic function by echocardiography and tissue Doppler echocardiographic evaluation and relationship serum N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) levels of women with polycystic ovary syndrome (PCOS).Materials and method: Thirty-two women with PCOS (age: 23.4–4.6 years; BMI: 23.8–4.8 kg/m2), similar age and BMI have features 30 healthy womens c...

Introduction and objective: Cardiovascular mortality is high in acromegaly. Our aim in this study was to determine the levels of the new cardiovascular marker in active acromegaly patients, the mean platelet volume (MPV) values before and after octreotide acetate long-acting repeatable treatment.Material and methods: Thirty-six patients with active acromegaly who presented at the Endocrinology Department (mean age 46.0±14.0 years and mean BMI: 30.4&...

Introduction and objective: Platelets play an important role in the development of thrombotic events. Increase of mean platelet volume (MPV) may indicate pre-thrombotic conditions as a new cardiovascular marker. Larger platelets have been reported to be metabolically more active than smaller ones. Our aim of present study is to evaluate MPV levels in patients with papillary thyroid cancer.Materials and methods: Forty-seven patients with newly diagnosis m...

Purpose: The aim of this study was to evaluate the association and frequency of thyroid autoimmunity in patients with empty sella syndrome and to evaluate the possible effects of thyroid auto-antibodies on clinical and laboratory findings in patients with empty sella syndrome.Materials and methods: We recruited 93 patients (female) and 22 male patients (mean age 55.51±14.82) who were admitted to the Endocrinology Clinic of Erzurum Regional Training ...